Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 22, Issue 9, Pages 879-885Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2019.1656616
Keywords
Snake bile; bile acids; anti-inflammatory effect; bioactive substances basis
Funding
- National Natural Science Foundation of China [31870330, 81373917, 81773869]
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A new bile acid tauro-16 beta-hydroxy-12 alpha-sulfate-5 beta-cholenoic acid (1), along with six known ones (2-7), was isolated from the snake bile. Its planar structure and relative configuration were elucidated based on extensive spectroscopic analyses. Moreover, compound 2 showed inhibitory effect on NO production in RAW 264.7 macrophages at non-cytotoxic concentration (20 mu M) with inhibitory rate of 69.7%.
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