Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 67, Issue 39, Pages 10968-10976Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b02544
Keywords
fatty food; food contact materials; endocrine disruptors; liquid-liquid extraction; liquid chromatography-mass spectrometry; methanol-associated sensitivity loss
Funding
- Ministry of Health, Czech Republic, under Conceptual development of research organization (National Institute of Public Health-NIPH) [IN: 75010330]
- ERDF/ESF under International competitiveness of NIPH in research, development and education in alternative toxicological methods [CZ.02.1.01/0.0/0.0/16_019/0000860]
- Charles University in Prague [SVV260440]
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Food contact materials (FCMs) may release their chemical components into food and thus raise safety concerns. This paper attempted to study the presence of four major groups of FCM-related endocrine disruptors in fatty food: dialkyl phthalates, bisphenols, printing ink photoinitiators, and polyfluoroalkyl substances. All 41 target compounds were analyzed simultaneously by means of liquid chromatography coupled to tandem mass spectrometry. The sample preparation was significantly streamlined to reduce analysis costs by employing acetonitrile extraction, extract modification by water, and refrigeration at 5 degrees C. The new method was validated and applied to 60 real samples, including edible oils, butter, and chocolate, where 16 target compounds were measured at levels <= 13000 ng/g. The study also described the blank level increase and sensitivity loss caused by impurities present in the HPLC methanol solvent.
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