Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 256, Issue -, Pages 234-249Publisher
ELSEVIER
DOI: 10.1016/j.jad.2019.06.010
Keywords
Bipolar disorder; Cognition; Electrophysiology; Biological markers; EEG/Event-related potentials
Categories
Funding
- Japan Agency for Medical Research and development (AMED) [20807226]
- CIHR
- AMED
- Takeda Science Foundation
- Uehara Memorial Foundation
- Healthy Brains for Healthy LivesPostdoctoral Fellowship
- Japan Society for the Promotion of Science
- TEIJIN PHARMA LIMITED
- Japan Health Foundation
- Meiji Yasuda Mental Health Foundation
- Mitsui Life Social Welfare Foundation
- SENSHIN Medical Research Foundation
- Health Science Center Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Daiichi Sankyo Scholarship Donation Program
- Magventure Inc.
- Japan Research Foundation for Clinical Pharmacology
- Naito Foundation
- KAKENHI [20807226]
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Background: Neurophysiology including P300, that is a typical index of event-related potential, may be potential biomarkers for bipolar disorder (BD) and it can be useful towards elucidating the pathophysiology of BD. However, previous findings from P300 studies were inconsistent due to the heterogeneity of research methods, which make it difficult to understand the neurobiological significance of them. The aim of this study is to conduct a meta-analysis on P300 in patients with BD. Method: A literature search was conducted using PubMed to identify studies that compared P300 event-related potential between patients with BD and healthy controls (HCs). We analyzed P300 indices such as amplitude and latency of P3a and P3b in auditory or visual paradigms. Further, moderator analyses were conducted to investigate the influence of patient characteristics (i.e. history of psychosis, diagnostic subcategories [BD-I/BD-II], and phase of illness [euthymic, manic, or depressive]) on P300 indices. Result: Out of 124 initial records, we included 30 articles (BD: N = 1331; HCs: N = 1818). Patients with BD showed reduced P3a and P3b amplitude in both paradigms and delayed P3b latency in auditory paradigms compared to HCs. There was no influence on the history of psychosis, diagnostic subcategories, or phase of illness on P300 indices. Limitation: The difference in medication use was difficult to control and it may affect the results. Conclusion: This meta-analysis provides evidence for P300 abnormalities in patients with BD compared to HCs. Our results suggest that P300 may be trait markers rather than state markers in this illness.
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