Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 17, Pages 3476-3480Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.07.011
Keywords
Mitochondria-targeting; Oxidative stress; Fluorescence probes
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Funding
- NIH [GM088795-01]
- NSF [1048655]
- NASA [MSGC R85197]
- MIIE [1204010]
- VPR-SI fund [R01386]
- Research Excellence Fund [R01121, R01323]
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Mitochondrial oxidative stress has been implicated in aging, neurodegenerative diseases, diabetes, stroke, ischemia/reperfusion injury, age-related macular degeneration (AMD) and cancer. Recently, we developed two new mitochondria-targeting fluorescent probes, MitoProbes I/II, which specifically localize in mitochondria and employed both in vivo and in vitro for detection of mitochondrial oxidative stress. Here, we report the design and synthesis of these agents, as well as their utility for real-time imaging of mitochondrial oxidative stress in cells. Published by Elsevier Ltd.
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