Journal
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
Volume 34, Issue 5, Pages 1233-1241Publisher
QUINTESSENCE PUBLISHING CO INC
DOI: 10.11607/jomi.7343
Keywords
metronidazole; nonsurgical pen-implant therapy; peri-implantitis; radiographic bone loss
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Purpose: To show the clinical and radiographic results of intrabony peri-implantitis lesions treated nonsurgically with adjunctive systemic metronidazole with a mean follow-up of 50 months. Materials and Methods: Subjects diagnosed with peri-implantitis (probing depth >= 5 mm with concomitant bleeding on probing and/or suppuration) with radiographic evidence of intrabony defects > 2 mm were included in this study. Implants affected received one session of nonsurgical mechanical debridement with ultrasonic and steel curettes. Systemic metronidazole was immediately prescribed for 7 days. Clinical and radiographic variables were registered at baseline and at the end of follow-up. Results: Eighteen patients and 25 implants were included in this investigation. At baseline, the mean radiographic bone level and intrabony component were 4.52 +/- 2.14 mm and 3.93 +/- 1.51 mm, respectively. After a mean follow-up of 54 (range: 12 to 108) months, the mean radiographic bone level reduction was 2.6 +/- 0.21 mm, and the intrabony component reduction was 2.85 +/- 0.37 mm (P < .05). A mean probing depth reduction of 4.66 +/- 1.33 mm was observed (P < .05). Conclusion: Within the limits of this study, nonsurgical treatment of peri-implantitis with the adjunctive administration of systemic metronidazole has shown potential effectiveness in terms of probing depth and radiographic defect reduction after a mean follow-up of 54 months.
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