Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/ijms20174171
Keywords
syntenin; membrane architecture; synapse; tumor metastasis; exosome biogenesis
Funding
- AMED [JP18ek0109311]
- JSPS KAKENHI [17K07086, 17K07121, 18H02536]
- Japan Epilepsy Research Foundation
- SENSHIN Medical Research Foundation
- Grants-in-Aid for Scientific Research [17K07121, 17K07086, 18H02536] Funding Source: KAKEN
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Syntenin is an adaptor-like molecule that has two adjacent tandem postsynaptic density protein 95/Discs large protein/Zonula occludens 1 (PDZ) domains. The PDZ domains of syntenin recognize multiple peptide motifs with low to moderate affinity. Many reports have indicated interactions between syntenin and a plethora of proteins. Through interactions with various proteins, syntenin regulates the architecture of the cell membrane. As a result, increases in syntenin levels induce the metastasis of tumor cells, protrusion along the neurite in neuronal cells, and exosome biogenesis in various cell types. Here, we review the updated data that support various roles for syntenin in the regulation of neuronal synapses, tumor cell invasion, and exosome control.
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