Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms20163896
Keywords
protein aggregation; redox; oxidative stress; proteinopathy
Funding
- Centre National de la Recherche Scientifique (CNRS)
- Institut Curie
- Doctoral School ABIES, AgroParisTech
- Doctoral School SDSV, Universite Paris-Saclay
- La Fondation pour la Recherche Medicale
- Institut National de la Recherche Agronomique (INRA)
- Inserm
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Compelling evidence supports a tight link between oxidative stress and protein aggregation processes, which are noticeably involved in the development of proteinopathies, such as Alzheimer's disease, Parkinson's disease, and prion disease. The literature is tremendously rich in studies that establish a functional link between both processes, revealing that oxidative stress can be either causative, or consecutive, to protein aggregation. Because oxidative stress monitoring is highly challenging and may often lead to artefactual results, cutting-edge technical tools have been developed recently in the redox field, improving the ability to measure oxidative perturbations in biological systems. This review aims at providing an update of the previously known functional links between oxidative stress and protein aggregation, thereby revisiting the long-established relationship between both processes.
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