Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/ijms20194664
Keywords
polymer scission; PLLA; magnetite; cytotoxicity; magnetism; in vitro degradation
Funding
- Spanish Ministry of Economy and Competitiveness (MINECO) [MAT2016-76039-C4-3-R]
- Basque Government Industry Department under the ELKARTEK program
- Basque Government Industry Department under HAZITEK program
- Basque Government Industry Department under PIBA program
- Portuguese Foundation for Science and Technology (FCT) [UID/FIS/04650/2013, POCI-01-0145-FEDER-028237, SFRH/BD/111478/2015]
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Magnetic biomimetic scaffolds of poly(L-lactide) (PLLA) and nanoparticles of magnetite (nFe(3)O(4)) are prepared in a wide ratio of compositions by lyophilization for bone regeneration. The magnetic properties, cytotoxicity, and the in vitro degradation of these porous materials are closely studied. The addition of magnetite at 50 degrees C was found to produce an interaction reaction between the ester groups of the PLLA and the metallic cations of the magnetite, causing the formation of complexes. This fact was confirmed by the analysis of the infrared spectroscopy and the gel permeation chromatography test results. They, respectively, showed a displacement of the absorption bands of the carbonyl group (C=O) of the PLLA and a scission of the polymer chains. The iron from the magnetite acted as a catalyser of the macromolecular scission reaction, which determines the final biomedical applications of the scaffolds-it does so because the reaction shortens the degradation process without appearing to influence its toxicity. None of the samples studied in the tests presented cytotoxicity, even at 70% magnetite concentrations.
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