Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/ijms20174126
Keywords
beta amyloid; aggregation state; small angle neutron scattering; Alzheimer's disease
Funding
- CNR, within the CNR-STFC Agreement 2014-2020 [3420]
Ask authors/readers for more resources
Aggregation states of amyloid beta peptides for amyloid beta A beta(1-40) to A beta(1-42) and A beta p(3-42) are investigated through small angle neutron scattering (SANS). The knowledge of these small peptides and their aggregation state are of key importance for the comprehension of neurodegenerative diseases (e.g., Alzheimer's disease). The SANS technique allows to study the size and fractal nature of the monomers, oligomers and fibrils of the three different peptides. Results show that all the investigated peptides have monomers with a radius of gyration of the order of 10 angstrom, while the oligomers and fibrils display differences in size and aggregation ability, with A beta p(3-42) showing larger oligomers. These properties are strictly related to the toxicity of the corresponding amyloid peptide and indeed to the development of the associated disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available