Related references
Note: Only part of the references are listed.Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway
Xiaoqin Ding et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs
Pelin Telkoparan-Akillilar et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction
Tom D. Heightman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Potential Applications of NRF2 Inhibitors in Cancer Therapy
Emiliano Panieri et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)
Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity
Meng-Chen Lu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation
Meng-Chen Lu et al.
REDOX BIOLOGY (2019)
Drug screening assay based on the interaction of intact Keap1 and Nrf2 proteins in cancer cells
Bo Zhou et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Development of a High-Throughput Cul3-Keap1 Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Identifying Nrf2 Activators
Derek D. Poore et al.
SLAS DISCOVERY (2019)
Fragment-based virtual screening approach and molecular dynamics simulation studies for identification of BACE1 inhibitor leads
Prabu Manoharan et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2018)
Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
Michael G. Erkkinen et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)
Design, synthesis, and evaluation of NDGA analogues as potential anti-ischemic stroke agents
Lili Huang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin
Lorraine M. Deck et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Discovery of a head-to-tail cyclic peptide as the Keapl-Nrf2 protein-protein interaction inhibitor with high cell potency
Meng-Chen Lu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis
Ning Meng et al.
FREE RADICAL BIOLOGY AND MEDICINE (2018)
Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy
Cheng-Shi Jiang et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)
Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity
Jiayu Zhu et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)
Transcriptional Regulation by Nrf2
Claudia Tonelli et al.
ANTIOXIDANTS & REDOX SIGNALING (2018)
Deep learning and virtual drug screening
Kristy A. Carpenter et al.
FUTURE MEDICINAL CHEMISTRY (2018)
Pharmacological Inhibition of LSD1 for Cancer Treatment
Guan-Jun Yang et al.
MOLECULES (2018)
Schisandrin B elicits the Keap 1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver
Shan Feng et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2018)
CPU Accelerated Quantum Virtual Screening: Application for the Natural Inhibitors of New Dehli Metalloprotein (NDM-1)
Mingsong Shi et al.
FRONTIERS IN CHEMISTRY (2018)
Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation
Kouhei Tsuchida et al.
FREE RADICAL BIOLOGY AND MEDICINE (2017)
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients
Luisa Quinti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Small molecules inhibiting Keap1-Nrf2 protein-protein interactions: a novel approach to activate Nrf2 function
Chunlin Zhuang et al.
MEDCHEMCOMM (2017)
Direct Keap 1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease
Fiona Kerr et al.
PLOS GENETICS (2017)
Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy
Yuki Yoshizaki et al.
SCIENTIFIC REPORTS (2017)
Oxidative Stress in Neurodegenerative Diseases
Ewa Niedzielska et al.
MOLECULAR NEUROBIOLOGY (2016)
Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
Anju Singh et al.
ACS CHEMICAL BIOLOGY (2016)
Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response
Yuxue Zhang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1
Mostafa M. Ghorab et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery
Thomas G. Davies et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update
Meng-Chen Lu et al.
MEDICINAL RESEARCH REVIEWS (2016)
NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer
Jaieun Kim et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Open challenges in structure-based virtual screening: Receptor modeling, target flexibility consideration and active site water molecules description
Francesca Spyrakis et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2015)
Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction
Geoff Wells
BIOCHEMICAL SOCIETY TRANSACTIONS (2015)
Role of growth hormone in maturation and activation of dendritic cells via miR-200a and the Keap1/Nrf2 pathway
Qiu-Liang Liu et al.
CELL PROLIFERATION (2015)
State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors
Chunquan Sheng et al.
CHEMICAL SOCIETY REVIEWS (2015)
Functional polymorphisms in Nrf2: implications for human disease
Hye-Youn Cho et al.
FREE RADICAL BIOLOGY AND MEDICINE (2015)
Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor
Zheng-Yu Jiang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction
Helene C. Bertrand et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
MUC1-C activates the TAK1 inflammatory pathway in colon cancer
H. Takahashi et al.
ONCOGENE (2015)
Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation
Seung Hee Choi et al.
VASCULAR PHARMACOLOGY (2015)
Expression of xCT and activity of system X-c(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress
Eric Habib et al.
REDOX BIOLOGY (2015)
Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents
Dhulfiqar Ali Abed et al.
ACTA PHARMACEUTICA SINICA B (2015)
Nrf2 and Redox Status in Prediabetic and Diabetic Patients
Angelica S. Jimenez-Osorio et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Rapid Identification of Keap1-Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search
Chunlin Zhuang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Discovery of Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis
Zheng-Yu Jiang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Novel protein-protein interaction inhibitor of Nrf2-Keap1 discovered by structure-based virtual screening
Hao-Peng Sun et al.
MEDCHEMCOMM (2014)
Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation Induces Myofibroblastic Dedifferentiation in Idiopathic Pulmonary Fibrosis
Elise Artaud-Macari et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism
Douglas Marcotte et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
Hongyan Wang et al.
CANCER RESEARCH (2013)
Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
Yoshinobu Ichimura et al.
MOLECULAR CELL (2013)
Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity
Rowena Hancock et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2013)
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
Meijuan Zhang et al.
PROGRESS IN NEUROBIOLOGY (2013)
Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction
Marjolein Schaap et al.
PROTEIN SCIENCE (2013)
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
Emilia Kansanen et al.
REDOX BIOLOGY (2013)
Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects
Carla Zoja et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)
Nrf2-keap1 system versus NF-κB: The good and the evil in chronic kidney disease?
Liliana Magnago Pedruzzi et al.
BIOCHIMIE (2012)
Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL
Hui Tian et al.
CANCER LETTERS (2012)
Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes
You-Cheng Hseu et al.
FOOD AND CHEMICAL TOXICOLOGY (2012)
Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction
Rowena Hancock et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents
Sadagopan Magesh et al.
MEDICINAL RESEARCH REVIEWS (2012)
Dietary modulation of the biotransformation and genotoxicity of aflatoxin B1
Kerstin Gross-Steinmeyer et al.
TOXICOLOGY (2012)
Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators
Natalya A. Smirnova et al.
CHEMISTRY & BIOLOGY (2011)
Druggability assessment of protein-protein interfaces
Jutta Wanner et al.
FUTURE MEDICINAL CHEMISTRY (2011)
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
Keiko Taguchi et al.
GENES TO CELLS (2011)
Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes
Pablo E. Pergola et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease
A. Boutten et al.
TRENDS IN MOLECULAR MEDICINE (2011)
Nrf2: friend or foe for chemoprevention?
Thomas W. Kensler et al.
CARCINOGENESIS (2010)
Hydrogen Peroxide Is a Second Messenger in Phase 2 Enzyme Induction by Cancer Chemopreventive Dithiolethiones
Ryan Holland et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2009)
Targeting the Nrf2 pathway against cardiovascular disease
Jinqing Li et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2009)
Molecular Mechanisms of Nrf2-Mediated Antioxidant Response
Wenge Li et al.
MOLECULAR CARCINOGENESIS (2009)
High-Throughput Affinity-Based Technologies for Small-Molecule Drug Discovery
Zhengrong Zhu et al.
JOURNAL OF BIOMOLECULAR SCREENING (2009)
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice
Keigyou Yoh et al.
GENES TO CELLS (2008)
Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease
Jose A. Obeso et al.
MOVEMENT DISORDERS (2008)
Dual roles of Nrf2 in cancer
Alexandria Lau et al.
PHARMACOLOGICAL RESEARCH (2008)
Different electrostatic Potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
Kit I. Tong et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment
William O. Osburn et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
ROS as signalling molecules:: mechanisms that generate specificity in ROS homeostasis
Benoit D'Autreaux et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
Changjiang Xu et al.
CANCER RESEARCH (2006)
Structure of the Keap1: Nrf2 interface provides mechanistic insight into Nrf2 signaling
Shih-Ching Lo et al.
EMBO JOURNAL (2006)
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
B Padmanabhan et al.
MOLECULAR CELL (2006)
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
H Okawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Nrf2 as a target for cancer chemoprevention
X Yu et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)
The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
P Nioi et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro
RJ Jakel et al.
TOXICOLOGICAL SCIENCES (2005)
ZINC - A free database of commercially available compounds for virtual screening
JJ Irwin et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)
BTB protein keap1 targets antioxidant transcription factor nrf2 for ubiquitination by the cullin 3-Roc1 ligase
M Furukawa et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
M McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Novel technologies for virtual screening
T Lengauer et al.
DRUG DISCOVERY TODAY (2004)
Docking and scoring in virtual screening for drug discovery: Methods and applications
DB Kitchen et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Quantitative structure-activity relationship methods: Perspectives on drug discovery and toxicology
R Perkins et al.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2003)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
Y Katoh et al.
GENES TO CELLS (2001)
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
M Ramos-Gomez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Progress in predicting human ADME parameters in silico
S Ekins et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2000)
Share Paper
