Journal
ATHEROSCLEROSIS
Volume 255, Issue -, Pages 11-16Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2016.10.032
Keywords
Arteries; Arterial ageing; Carotid intima-media thickness; Metabolic syndrome
Funding
- Fund for Scientific Research - Flanders (FWO) [G042703, G083810N]
- Erasmus Medical Center and Erasmus University Rotterdam
- Netherlands Organization for Scientific Research
- Netherlands Organization for Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Netherlands Heart Foundation
- Ministry of Education, Culture and Science
- Ministry of Health Welfare and Sports
- European Commission
- Municipality of Rotterdam
- NIA [NO1-AG-1-2109]
- Intramural Research Program of the NIH, National Institute on Aging (USA)
- Federal Ministry of Education and Research
- Federal State of Mecklenburg-West Pomerania
- Research Institute of Medical Sciences, Chonnam National University
- Intramural Research Program of the NIH, National Institute on Aging
- National Science Council (NSC) [99-2314-B-010-034-MY3]
- Taipei Veterans General Hospital [V102C-119]
- Intramural Research Program of the National Institute on Aging, National Institutes of Health
- Swedish Research Council [K2008-65X-20752-01-3, K2011-65X-20752-04-6]
- Lundstroms Foundation
- Swedish Heart-Lung Foundation [2010-0244, 2013-0249]
- ALF government grants [2012/1789]
- [NO1-AG-1-2118]
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Background and aims: We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods: We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results: Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50-90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7-8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher. Conclusions: The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better - i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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