4.7 Review

Potential for Tight Junction Protein-Directed Drug Development Using Claudin Binders and Angubindin-1

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Morphologic determinant of tight junctions revealed by claudin-3 structures

Shun Nakamura et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Structural dynamics of tight junctions modulate the properties of the epithelial barrier

Aapo Tervonen et al.

PLOS ONE (2019)

Review Pharmacology & Pharmacy

Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs

Yosuke Hashimoto et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Imaging of Claudin-4 in Pancreatic Ductal Adenocarcinoma Using a Radiolabelled Anti-Claudin-4 Monoclonal Antibody

Julia Baguna Torres et al.

MOLECULAR IMAGING AND BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia

C. Greene et al.

MOLECULAR PSYCHIATRY (2018)

Article Pharmacology & Pharmacy

Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2

Yosuke Hashimoto et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Article Chemistry, Multidisciplinary

Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system

Satoshi Zeniya et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Article Multidisciplinary Sciences

Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5

Yosuke Hashimoto et al.

SCIENTIFIC REPORTS (2018)

Article Gastroenterology & Hepatology

Claudin-3 regulates bile canalicular paracellular barrier and cholesterol gallstone core formation in mice

Hiroo Tanaka et al.

JOURNAL OF HEPATOLOGY (2018)

Article Multidisciplinary Sciences

A molecular atlas of cell types and zonation in the brain vasculature

Michael Vanlandewijck et al.

NATURE (2018)

Article Multidisciplinary Sciences

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

Liqun He et al.

SCIENTIFIC DATA (2018)

Review Physiology

Claudins in cancer: bench to bedside

Makoto Osanai et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2017)

Article Chemistry, Multidisciplinary

Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction

Susanne M. Krug et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Oncology

Antibody targeting of claudin-1 as a potential colorectal cancer therapy

S. Cherradi et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

Article Pharmacology & Pharmacy

Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model

Yosuke Hashimoto et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

Article Pharmacology & Pharmacy

Creation of a Claudin-2 Binder and Its Tight Junction-Modulating Activity in a Human Intestinal Models

Mutsumi Takigawa et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

Article Cell Biology

Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1

Christina M. Van Itallie et al.

MOLECULAR BIOLOGY OF THE CELL (2017)

Article Neurosciences

Social stress induces neurovascular pathology promoting depression

Caroline Menard et al.

NATURE NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

ILDR1 is important for paracellular water transport and urine concentration mechanism

Yongfeng Gong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Multidisciplinary Sciences

Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer

Yosuke Hashimoto et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

Article Biochemistry & Molecular Biology

Generation and characterization of a human-mouse chimeric antibody against the extracellular domain of claudin-1 for cancer therapy using a mouse model

Yosuke Hashimoto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Review Pharmacology & Pharmacy

Current progress in a second-generation claudin binder, anti-claudin antibody, for clinical applications

Yosuke Hashimoto et al.

DRUG DISCOVERY TODAY (2016)

Article Multidisciplinary Sciences

Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis

Reitaro Tokumasu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions

Barbara Schlingmann et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin

Takehiro Shinoda et al.

SCIENTIFIC REPORTS (2016)

Article Pharmacology & Pharmacy

Efficacy and safety evaluation of claudin-4-targeted antitumor therapy using a human and mouse cross-reactive monoclonal antibody

Yosuke Hashimoto et al.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2016)

Article Biochemistry & Molecular Biology

Generation of specific monoclonal antibodies against the extracellular loops of human claudin-3 by immunizing mice with target-expressing cells

Hiroshi Ando et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Model for the Architecture of Claudin-Based Paracellular Ion Channels through Tight Junctions

Hiroshi Suzuki et al.

JOURNAL OF MOLECULAR BIOLOGY (2015)

Article Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

Heitor S. P. de Souza et al.

Nature Reviews Gastroenterology & Hepatology (2015)

Article Multidisciplinary Sciences

Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin

Yasunori Saitoh et al.

SCIENCE (2015)

Article Biochemistry & Molecular Biology

Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5

Jonas Protze et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

Article Pharmacology & Pharmacy

Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model

Misaki Nakajima et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Review Pharmacology & Pharmacy

A 21st-century approach to age-old problems: the ascension of biologics in clinical therapeutics

Michael J. Espiritu et al.

DRUG DISCOVERY TODAY (2014)

Article Multidisciplinary Sciences

Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions

Hiroshi Suzuki et al.

SCIENCE (2014)

Article

Cutaneous Drug Delivery: An Update

Thanh-Nga T. Tran

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS (2013)

Article Engineering, Biomedical

Creation and biochemical analysis of a broad-specific claudin binder

Azusa Takahashi et al.

BIOMATERIALS (2012)

Article Multidisciplinary Sciences

Claudin-4 Deficiency Results in Urothelial Hyperplasia and Lethal Hydronephrosis

Harumi Fujita et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

Predicted expansion of the claudin multigene family

Katsuhiko Mineta et al.

FEBS LETTERS (2011)

Article Immunology

Clostridium perfringens Iota-Toxin b Induces Rapid Cell Necrosis

Masahiro Nagahama et al.

INFECTION AND IMMUNITY (2011)

Article Biochemistry & Molecular Biology

Crystal Structure of Clostridium perfringens Enterotoxin Displays Features of β-Pore-forming Toxins

Kengo Kitadokoro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Cell Biology

LSR defines cell corners for tricellular tight junction formation in epithelial cells

Sayuri Masuda et al.

JOURNAL OF CELL SCIENCE (2011)

Article Cell Biology

Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens

Yuji Yamazaki et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Article Multidisciplinary Sciences

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

Panagiotis Papatheodorou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Pharmacology & Pharmacy

A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide

Hiroshi Uchida et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Article Engineering, Biomedical

Mucosal vaccination using claudin-4-targeting

Hideki Kakutani et al.

BIOMATERIALS (2010)

Article Gastroenterology & Hepatology

Monoclonal Anti-Claudin 1 Antibodies Prevent Hepatitis C Virus Infection of Primary Human Hepatocytes

Isabel Fofana et al.

GASTROENTEROLOGY (2010)

Article Physiology

Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine

Alexander G. Markov et al.

JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY (2010)

Article Multidisciplinary Sciences

Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules

Shigeaki Muto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Molecular Determinants of the Interaction between Clostridium perfringens Enterotoxin Fragments and Claudin-3

Lars Winkler et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Pharmacology & Pharmacy

A Novel Tumor-Targeted Therapy Using a Claudin-4-Targeting Molecule

Rie Saeki et al.

MOLECULAR PHARMACOLOGY (2009)

Article Biochemistry & Molecular Biology

Formation of tight junction: determinants of homophilic interaction between classic claudins

Joerg Piontek et al.

FASEB JOURNAL (2008)

Article Gastroenterology & Hepatology

M1994 Selective Up-Regulation of Claudin-1 and Claudin-2 in Colorectal Cancer

Tetsushi Kinugasa

GASTROENTEROLOGY (2008)

Article Cell Biology

Molecular composition of tight and adherens junctions in the rat olfactory epithelium and fila

Axel Steinke et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2008)

Article Medicine, Research & Experimental

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

Christopher R. Weber et al.

LABORATORY INVESTIGATION (2008)

Review Biochemistry & Molecular Biology

Claudins: multifunctional players in epithelial tight junctions and their role in cancer

S. S. Oliveira et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

Review Genetics & Heredity

Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia

Tadao Arinami

JOURNAL OF HUMAN GENETICS (2006)

Article Cell Biology

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

J Ikenouchi et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia

J Wei et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2005)

Article Medicine, Research & Experimental

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

P Dhawan et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Article Pharmacology & Pharmacy

A novel strategy for the enhancement of drug absorption using a claudin modulator

M Kondoh et al.

MOLECULAR PHARMACOLOGY (2005)

Article Psychiatry

The CLDN5 locus may be involved in the vulnerability to schizophrenia

ZY Sun et al.

EUROPEAN PSYCHIATRY (2004)

Article Immunology

Binding and internalization of Clostridium perfringens iota-toxin in lipid rafts

M Nagahama et al.

INFECTION AND IMMUNITY (2004)

Article Cell Biology

Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice

T Nitta et al.

JOURNAL OF CELL BIOLOGY (2003)

Review Cell Biology

Claudin-based barrier in simple and stratified cellular sheets

S Tsukita et al.

CURRENT OPINION IN CELL BIOLOGY (2002)

Article Gastroenterology & Hepatology

Claudin-4:: A new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin

P Michl et al.

GASTROENTEROLOGY (2001)

Article Cell Biology

Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers

CJ Watson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)

Article Cell Biology

Osmotic opening of the blood-brain barrier: Principles, mechanism, and therapeutic applications

SI Rapoport

CELLULAR AND MOLECULAR NEUROBIOLOGY (2000)