Journal
ATHEROSCLEROSIS
Volume 245, Issue -, Pages 139-142Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2015.12.011
Keywords
Atherosclerosis; Carotid plaques; Polymorphisms; Rheumatoid arthritis; Vitamin D receptor
Funding
- European Union FEDER funds
- Fondo de Investigacion Sanitaria from 'Instituto de Salud Carlos III' (ISCIII, Health Ministry, Spain) [PI06/0024, PS09/00748, PI12/00060]
- RETICS Programs (RIER) from 'Instituto de Salud Carlos III' (ISCIII, Health Ministry, Spain) [RD12/0009]
- European IMI BTCure Program
- Instituto Carlos III de Salud at the Spanish Ministry of Health (Spain) [CD12/00425]
- RETICS Program (RIER) [RD12/0009/0013]
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Introduction: An association between the vitamin D receptor (VDR) GAT haplotype and coronary artery disease (CAD) in type-2 diabetes has recently been described. Since cardiovascular mortality in rheumatoid arthritis (RA) is comparable to that observed for patients with type-2 diabetes, we aimed to determine if VDR GAT haplotype is also associated with atherosclerotic disease in RA. Material and Methods: 591 Northern Spanish RA patients were genotyped for 4 VDR polymorphisms (rs731236 A/G; rs7975232 A/C; rs1544410C/T; rs2228570 G/A). Atherosclerotic disease was established by the presence of carotid plaques in carotid ultrasound. Results: VDR rs7975232 AA genotype was increased in RA patients with plaques (p = 0.045, OR = 1.46 [1.01-2.18]). More importantly, the frequency of carotid plaques was significantly increased in RA patients who carried the GATG haplotype (p = 0.009, OR = 1.56 [1.09-2.42]). Conclusion: Our results suggest a potential VDR GATG haplotype association with atherosclerotic disease in RA patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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