Journal
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
Volume 34, Issue 12, Pages 1883-1891Publisher
WILEY
DOI: 10.1002/gps.5205
Keywords
APOE genotype; cognition; cognitive status; dementia; depressive symptoms; education; memory and learning tests; mild cognitive impairment; sex differences; telephone screening
Categories
Funding
- Suomen Aivosaatio
- Suomen Kulttuurirahasto
- Yrjo Jahnssonin Saatio
- Finnish Brain Foundation
- Turku University Foundation
- Yrjo Jahnsson Foundation
- Finnish Cultural Foundation
- Academy of Finland [265240, 308248, 312073, 314639, 320109, 133193, 310962]
- Finnish Governmental Research Funding
- Sigrid Juselius Foundation
- Academy of Finland (AKA) [314639, 320109, 133193, 320109, 133193, 314639] Funding Source: Academy of Finland (AKA)
Ask authors/readers for more resources
Objectives The modified Telephone Interview for Cognitive Status (TICS-m) is an efficient and cost-effective screening instrument of dementia, but there is less support for its utility in the detection of mild cognitive impairment (MCI). We undertook a comprehensive evaluation of the utility of different TICS-m versions with or without an education-adjusted scoring method to classify dementia and MCI in a large population-based sample. Methods Cross-sectional assessment of cognition (TICS-m), depressive symptoms (CES-D), and apolipoprotein E (APOE) epsilon 4 status was performed on 1772 older adults (aged 71-78 y, education 5-16 y, 50% female) from the population-based older Finnish Twin Cohort. TICS-m classification methods with and without education adjustment were used to classify individuals with normal cognition, MCI, or dementia. Results The prevalence of dementia and MCI varied between education-adjusted (dementia = 3.7%, MCI = 9.3%) and unadjusted classifications (dementia = 8.5%-11%, MCI = 22.3%-41.3%). APOE epsilon 4 status was associated with dementia irrespective of education adjustment, but with MCI only when education adjustment was used. Regardless of the version, poorer continuous TICS-m scores were associated with higher age, lower education, more depressive symptoms, male sex, and being an APOE epsilon 4 carrier. Conclusions We showed that demographic factors, APOE epsilon 4 status, and depressive symptoms were similarly related to continuous TICS-m scores and dementia classifications with different versions. However, education-adjusted classification resulted in a lower prevalence of dementia and MCI and in a higher proportion of APOE epsilon 4 allele carriers among those identified as having MCI. Our results support the use of education-adjusted classification especially in the context of MCI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available