Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 146, Issue 6, Pages 1754-1763Publisher
WILEY
DOI: 10.1002/ijc.32647
Keywords
circular RNA; CircPanel; diagnosis; hepatocellular carcinoma; plasma
Categories
Funding
- National Human Genetic Resources Sharing Service Platform [2005DKA21300]
- National Key Basic Research Programof China [2014CB542102]
- National Key Research and Development Program of China [2016YFC1302303]
- National Natural Science Foundation of China [81672345, 81772529]
- Science Fund for Creative Research Groups, NSFC, China [81521091]
- Shanghai Sailing Program [19YF1459600]
- State key infection disease project of China [2018ZX10732202-002-005]
- State Key Program of National Natural Science Foundation of China [81330037]
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To explore whether plasma circular RNAs (circRNAs) can diagnose hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), microarray and qPCR were used to identify plasma circRNAs that were increased in HBV-related HCC patients compared to controls (including healthy controls, chronic hepatitis B and HBV-related liver cirrhosis). A logistic regression model was constructed using a training set (n = 313) and then validated using another two independent sets (n = 306 and 526, respectively). Area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. We identified a plasma circRNA panel (CircPanel) containing three circRNAs (hsa_circ_0000976, hsa_circ_0007750 and hsa_circ_0139897) that could detect HCC. CircPanel showed a higher accuracy than AFP (alpha-fetoprotein) to distinguish individuals with HCC from controls in all three sets (AUC, 0.863 [95% confidence interval, CI: 0.819-0.907] vs. 0.790 [0.738-0.842], p = 0.036 in training set; 0.843 [0.796-0.890] vs. 0.747 [0.691-0.804], p = 0.011 in validation set 1 and 0.864 [0.830-0.898] vs. 0.769 [0.728-0.810], p < 0.001 in validation set 2). CircPanel also performed well in detecting Small-HCC (solitary, <= 3 cm), AFP-negative HCC and AFP-negative Small-HCC.
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