Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 134, Issue -, Pages 91-99Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.04.195
Keywords
Hydrogel; Chitosan; Cordycepin
Funding
- National Natural Science Foundation of China [81673719, 21473257, 21773311]
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The chitosan-based hydrogel dressings have been intensively engaged in wound healing. In respect to the relatively unsatisfied anti-bacterial performance of chitosan, we developed a self-healable cordycepin (abbreviated to CY)/chitosan (abbreviated to CS) hydrogel dressing cross linking by non-covalent bonds (hydrogen bond and electrostatic interaction) for wound healing through one-step 'freeze-thaw' method without adding any cross-linking agent. The as-prepared hybrid hydrogel exhibited excellent biocompatibility, suitable swelling ratio and desired mechanical strength, providing remarkable antimicrobial effect with no side effects in vitro. The self-healable property enables this hydrogel to adapt irregularly shaped wound defects without premolding. Moreover, our in vivo experiments confirmed that CY/CS hydrogel served as a quicker re-epithelization of skin wounds and an apparent increasing collagen deposition compared with chitosan hydrogels. Additionally, the CY/CS hydrogel significantly increased the expressions of epithelial regeneration markers including laminin and involucrin. The present study highlights a facile hydrogel strategy to balance and optimize the biocompatibility, swelling ratio and self-adapting ability for treating wound healing. (C) 2019 Elsevier B.V. All rights reserved.
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