Journal
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
Volume 58, Issue 33, Pages 15079-15087Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.iecr.9b02196
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Funding
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01EB022025]
- Cockrell Family Chair Foundation
- Cockrell School of Engineering at the University of Texas at Austin (UT)
- UT-Portugal Collaborative Research Program
- National Science Foundation Graduate Research Fellowship [DGE-1610403]
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Alzheimer's disease is an irreversible neuro-degenerative disorder affecting approximately 6 million Americans, 90% of which are over the age of 65. The hallmarks of the disease are represented by amyloid plaques and neurofibrillary tangles. While the neuronal characteristics of Alzheimer's disease are well-known, current treatments only provide temporary relief of the disease symptoms. Many of the approved therapeutic agents for the management of cognitive impairments associated with the disease are based on neurotransmitter or enzyme modulation. However, development of new treatment strategies is limited due to failures associated with poor drug solubility, low bioavailability, and the inability to overcome obstacles present along the drug delivery route. In addition, treatment technologies must overcome the challenges presented by the blood-brain barrier. This complex and highly regulated barrier surveys the biochemical, physicochemical, and structural features of nearby molecules at the periphery, only permitting passage of select molecules into the brain. To increase drug efficacy to the brain, many nanotechnology-based platforms have been developed. These methods for assisted drug delivery employ sophisticated design strategies and offer serveral advantages over traditional methods. For example, nanoparticles are generally low-cost technologies, which can be used for noninvasive administrations, and formulations are highly tunable to increase drug loading, targeting, and release efficacy. These nanoscale systems can facilitate the passage of drugs through the blood-brain barrier, thus improving the bioavailability, pharmacokinetics, and pharmacodynamics of therapeutic agents. Examples of such nanocarriers that are discussed herein include polymeric nanoparticles, dendrimers, and lipid-based nanoparticles.
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