Journal
IMMUNOGENETICS
Volume 71, Issue 8-9, Pages 513-518Publisher
SPRINGER
DOI: 10.1007/s00251-019-01127-8
Keywords
T cells; Positive and negative selection; Self/nonself discrimination
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Demonstration that immature CD4+8+ thymocytes contain T cell precursors that are subjected to positive and negative selection was the major step towards understanding how the adaptive immune system acquires the ability to distinguish foreign or abnormal (mutated or infected) self-cells from normal (healthy) cells. In the present review, the roles of TCR, CD4, CD8, and MHC molecules in intrathymic selection and some of the crucial experiments that contributed to the solution of the great immunological puzzle of self/nonself discrimination are described in an historical perspective. Recently, these experiments were highlighted by the immunological community by awarding the 2016 Novartis Prize for Immunology to Philippa Marrack, John Kappler, and Harald von Boehmer.
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