Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 20, Pages 4597-4600Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.08.052
Keywords
Quencher-free molecular beacon; Aptamer molecular beacons; Aptamer; Pyrene; Fluorescence sensor
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Funding
- NRF of Korea [2012R1A2A2A01047069, 2010-0005986]
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We have constructed a simple and efficient system-based on quencher-free molecular aptamer beacons (QF-MABs)-for probing ATP. In the absence of ATP, the fluorescence of a pyrene fluorophore on the loop position (15 nucleotides from the 5' end) of the optimal QF-MAB was quenched by the neighboring nucleobases; in its presence, fluorescence was recovered, due to a conformational change in the secondary structure of the QF-MAB. (C) 2015 Elsevier Ltd. All rights reserved.
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