Journal
IEEE TRANSACTIONS ON MEDICAL IMAGING
Volume 38, Issue 8, Pages 1923-1934Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2019.2893117
Keywords
Termination detection; neuron reconstruction; multiscale ray-shooting model; rayburst sampling
Categories
Funding
- National Natural Science Foundation of China [61771189]
- Hunan Key Laboratory of Intelligent Robot Technology in Electronic Manufacturing [IRT2018007]
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Digital reconstruction (tracing) of tree-like structures, such as neurons, retinal blood vessels, and bronchi, from volumetric images and 2D images is very important to biomedical research. Many existing reconstruction algorithms rely on a set of good seed points. The 2D or 3D terminations are good candidates for such seed points. In this paper, we propose an automatic method to detect terminations for tree-like structures based on a multiscale ray-shooting model and a termination visual prior. The multiscale ray-shooting model detects 2D terminations by extracting and analyzing the multiscale intensity distribution features around a termination candidate. The range of scale is adaptively determined according to the local neurite diameter estimated by the Rayburst sampling algorithm in combination with the gray-weighted distance transform. The termination visual prior is based on a key observation-when observing a 3D termination from three orthogonal directions without occlusion, we can recognize it in at least two views. Using this prior with the multiscale ray-shooting model, we can detect 3D terminations with high accuracies. Experiments on 3D neuron image stacks, 2D neuron images, 3D bronchus image stacks, and 2D retinal blood vessel images exhibit average precision and recall rates of 87.50% and 90.54%. The experimental results confirm that the proposed method outperforms other the state-of-the-art termination detection methods.
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