Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 12, Pages 2555-2558Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.04.048
Keywords
Caryopteris mongolica; Abietane diterpenoid; ortho-Quinone; Methylcyclopropane; Gram-positive bacteria
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Funding
- Kanae Foundation for the Promotion of Medical Science
- JSPS KAKENHI [26860068]
- Grant for Research Support Year at the National University of Mongolia
- Honda Foundation of Japan
- Grants-in-Aid for Scientific Research [26860068] Funding Source: KAKEN
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To identify antibacterial components in traditional Mongolian medicinal plant Caryopteris mongolica, an ortho-quinone abietane caryopteron A (1) and three its derivatives caryopteron B-D (2-4) were isolated from the roots of the plant together with three known abietanes demethylcryptojaponol (5), 6 alpha-hydroxydemethyl cryptojaponol (6), and 14-deoxycoleon U (7). The chemical structures of these abietane derivatives were elucidated on the basis of spectroscopic data. Compounds 1-4 had C-13 methylcyclopropane substructures, and 2-4 had a hexanedioic anhydride ring C instead of ortho-quinone in 1. The stereochemistry of these compound was assumed from NOE spectra and ECD Cotton effects. Compounds 1 and 5-7 showed antibacterial activities against the Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Micrococcus luteus, being 1 the more potent. (C) 2015 Elsevier Ltd. All rights reserved.
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