Journal
GENES AND NUTRITION
Volume 14, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12263-019-0650-x
Keywords
Caenorhabditis elegans; Aging; Longevity; Dietary restriction; Autophagy; HLH-30; TFEB; Metabolism; Epigenetics
Categories
Funding
- Independent Research Fund Denmark-Natural Sciences
Ask authors/readers for more resources
Decline of cellular functions especially cognitive is a major deficit that arises with age in humans. Harnessing the strengths of small and genetic tractable model systems has revealed key conserved regulatory biochemical and signaling pathways that control aging. Here, we review some of the key signaling and biochemical pathways that coordinate aging processes with special emphasis on Caenorhabditis elegans as a model system and discuss how nutrients and metabolites can regulate lifespan by coordinating signaling and epigenetic programs. We focus on central nutrient-sensing pathways such as mTOR and insulin/insulin-like growth factor signaling and key transcription factors including the conserved basic helix-loop-helix transcription factor HLH-30/TFEB.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available