Journal
GENES & DEVELOPMENT
Volume 33, Issue 17-18, Pages 1098-1116Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.327312.119
Keywords
gene regulation; genomics; KRAB zinc finger; fetrotransposons; transposable elements; piRNA
Categories
Funding
- National Institutes of Health [R35GM122550, U01HG009391, R01GM112972]
Ask authors/readers for more resources
Transposable elements (TEs) are mobile DNA sequences that colonize genomes and threaten genome integrity. As a result, several mechanisms appear to have emerged during eukaryotic evolution to suppress TE activity. However, TEs are ubiquitous and account for a prominent fraction of most eukaryotic genomes. We argue that the evolutionary success of TEs cannot be explained solely by evasion from host control mechanisms. Rather, some TEs have evolved commensal and even mutualistic strategies that mitigate the cost of their propagation. These co-evolutionary processes promote the emergence of complex cellular activities, which in turn pave the way for cooption of TE sequences for organismal function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available