Journal
GENES & DEVELOPMENT
Volume 33, Issue 19-20, Pages 1295-1318Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.329771.119
Keywords
MITF; phenotypic plasticity; melanoma; microenvironment; cancer
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Funding
- Ludwig Institute for Cancer Research
- National Institutes of Health [PO1 CA128814-06A1]
- Melanoma Research Alliance (MRA) [623591]
- Stichting Tegen Kanker (STK)
- Interreg (Skin-Huid)
- FWO [G.0929.16N]
- KUL
- Omics/Marie Curie@VIB
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An incomplete view of the mechanisms that drive metastasis, the primary cause of cancer-related death, has been a major barrier to development of effective therapeutics and prognostic diagnostics. Increasing evidence indicates that the interplay between microenvironment, genetic lesions, and cellular plasticity drives the metastatic cascade and resistance to therapies. Here, using melanoma as a model, we outline the diversity and trajectories of cell states during metastatic dissemination and therapy exposure, and highlight how understanding the magnitude and dynamics of nongenetic reprogramming in space and time at single-cell resolution can be exploited to develop therapeutic strategies that capitalize on nongenetic tumor evolution.
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