Journal
GENE
Volume 714, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.gene.2019.143955
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Funding
- Pamukkale University Scientific Research Committee [2016HZDP0030]
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Aim: MYC deregulation contributes to breast cancer development and progression. Deregulated expression levels of long non-coding RNAs (lncRNA) have been demonstrated to be critical players in development and/or maintenance of breast cancer. In this study we aimed to evaluate lncRNA expressions depending on MYC overexpression and knockdown in breast cancer cells. Materials and methods: Cells were infected with lentiviral vectors by either knockdown or overexpression of c-MYC. LncRNA cDNA was transcribed from total RNA samples and lncRNAs were evaluated by qRT-PCR. Results: Our results indicated that some of the lncRNAs having tumor suppressor (GASS, MEG3, lincRNA-p21) and oncogenic roles (HOTAIR) are regulated by c-MYC. Conclusion: We observed that c-MYC regulates lncRNAs that have important roles on proliferation, cell cycle and etc. Further studies will give us a light to identify molecular mechanisms related to MYC-lncRNA regulatory pathways in breast cancer.
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