Journal
FUTURE ONCOLOGY
Volume 15, Issue 26, Pages 3081-3095Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2019-0187
Keywords
carbon therapy; gynecological carcinoma; Systematic Review
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Funding
- Lanzhou Innovation and Entrepreneurship Talent Project [2017RC-23]
- Hospital Fund Project of the First Hospital of Lanzhou University [ldyyyn2018-09]
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This Systematic Review summarizes the literatures of clinical trials on the efficacy and safety of carbon ion therapy for gynecological carcinomas. The protocol is detailed in the online PROSPERO database, registration no. CRD42019121424, and a final set of eight studies were included. In the treatment of cervical carcinomas, both carbon ion therapy alone and carbon ion therapy concurrent chemotherapy have presented good efficacy. Besides, the efficacy of inoperable endometrial carcinomas and gynecological melanoma are similar to that of surgical treatment. In terms of safety, gastrointestinal and genitourinary toxicities are low and could be controlled by limiting the volume and dose of intestinal tract and bladder. Carbon ion radiotherapy could be considered a safe, effective and feasible therapy for gynecological carcinomas.
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