Journal
FOOD CHEMISTRY
Volume 289, Issue -, Pages 701-707Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2019.03.097
Keywords
Magnetic solid phase extraction; High resolution mass spectrometry; Sulfonamides; Sample preparation; Carbon nanotubes
Funding
- National Natural Sciences Foundation of China [21205058, 21607020, 31500080]
- Fundamental Research Funds for the Central Universities [DUT17LK40]
- PetroChina Innovation Foundation [2017D-5007-0609]
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A simple modification method was developed for the functionalization of amino terminated carbon nanotubes (CNT-NH2) by using isocyanates as modifiers via the nucleophilic addition reaction. Two types of functionalized magnetic carbon nanotubes (MCNT) were prepared through deposition of magnetic nanoparticles on CNT-NH2 and modification with different isocyanates. p-Tolyl-functionalized MCNT (Tol-MCNT) with better adsorption performance were selected as adsorbent for magnetic solid phase extraction (MSPE), which could extract sulfonamides (SAs) from various milk samples with a enrichment factor of about 30 after optimization. By combining the MSPE with liquid chromatography-high resolution mass spectrometry (LC-HRMS), a new method was developed. Both skimmed and whole milk samples of three brands were analyzed with this method, and 4 SAs including sulfadiazine, sulfisomidine, sulfamethazine and sulfameter were detected with the concentration from unquantifiable to 72 ng/L, which were all well below the maximum residue limits in milk according to the regulations of China and EU.
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