Experimental investigation and modeling of the solubility of oxcarbazepine (an anticonvulsant agent) in supercritical carbon dioxide

To produce micro- or nano-sized particles of a solid solute drug, it is necessary to investigate their solubility behavior in supercritical carbon dioxide (SC-CO2). In this study, for the first time, solubility of Oxcarbazepine (as anticonvulsant agent) in SC-CO2 was determined using static method. For this purpose, experiments were performed at different operating temperatures (308-338 K) and pressures (120-270 bar), and feasible molar solubilities were found to range from 1.100 x 10(-7) to 2.675 x 10(-5). Three different groups of methods were applied to correlate the solubility data of Oxcarbazepine, including (1) two equations of state (EoSs), namely Peng-Robinson (PR) and PRSV equation of state (vdW2 mixing rules), (2) six density-based semi-empirical models, namely Sodeifian et al., Chrastil, Bartle et al., Garlapati et al., Mendez-Santiago and Teja (MST), and Kumar and Johnston (K-J), and (3) Wilson's model. Statistical analysis of the results revealed superiority of Peng-Robinson model over the other models. Experimental data consistency was performed on various semi empirical models. Finally, the approximate values of total (Delta H-total), vaporization (Delta H-vap), and solvation (Delta H-sol) enthalpies were calculated for OXC. (C) 2019 Elsevier B.V. All rights reserved.