Journal
FITOTERAPIA
Volume 137, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2019.104278
Keywords
Xylaria longipes; Cytochalasans; Cytotoxicity
Categories
Funding
- National Natural Science Foundation of China [31801789, 31560010, 31870513, 81872762, 81773590, 81561148013, 21502239, 81803395]
- National Key RD Plan [2017YFC1704007]
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Five new cytochalasans (1-5) were isolated from the rice fermentation of fungus Xylaria longipes, along with seven known compounds cytochalasin P (6), cytochalasin D (7), zygosporin D (8), 7-O-acetylcytochalasin D (9), cytochalasin C (10), 6,7-dihydro-7-oxo-cytochalasin C (11), and 6,7-dihydro-7-oxo-deacetylcytochalasin C (12). Thcir structures and absolute configurations were determined by extensive experimental spectroscopic methods as well as ECD calculation and CIAO C-13 NMR calculation. The cytotoxicity of obtained compounds (1 12) was evaluated against human cancer cell lines HL-60, A549, SMMC-7721, MCF-7, and SW480. Compounds 6-8, 11, and 12 showed cytotoxicity with IC50 value ranging from 4.17-37.18 mu M.
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