4.6 Review

Plant-derived bioadhesives for wound dressing and drug delivery system

Journal

FITOTERAPIA
Volume 137, Issue -, Pages -

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ELSEVIER
DOI: 10.1016/j.fitote.2019.104241

Keywords

Bioadhesives; Controlled drug delivery system; Excipients; Drug formulation; Gums; Mucilage

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Synthetic polymers have been widely used in various biomedical applications like drug delivery, wound dressing, etc. They pose a question of bio-compatibility and bio-accumulation, limiting to a minimum class of synthetic polymers to be efficient and versatile. Hence, one cheap and reliant replacement is the use of natural adhesives over the synthetic adhesive polymeric system. The pluripotency of plant could be exploit, making it a perfect candidate for extraction of plant-derived adhesives component for wound dressing and drug delivery system in large-scale production. Current advancement use excipients which influence, the rate of drug release and absorption. Properties like matrix formation and environment responsive gelation can be exploited through these plant-derived components for controlled drug release according to specific therapeutic requirement. This review explores such plant-derived bioactive component: Mucilage and gums, their isolation, and characterization which can be exploited as excipients in the formulation of drug delivery system as well as a wound dressing.

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