Journal
FEBS LETTERS
Volume 593, Issue 20, Pages 2817-2839Publisher
WILEY
DOI: 10.1002/1873-3468.13608
Keywords
cell cycle; epigenetics; fatty acid metabolism; glutamine metabolism; glycolysis; metabolism; nucleotide metabolism; oxidative phosphorylation; quiescence; stem cells
Funding
- NIH/NCI [1 R01 CA221296-01A1]
- Melanoma Research Alliance Team Science Award
- Cancer Research Institute Clinical Laboratory Integration Program Award
- University of California Cancer Research Coordinating Committee
- David Geffen School of Medicine Metabolism Theme Award
- Clinical Translational Science Institute
- Prostate Cancer Spore at UCLA
- Broad Stem Cell Center
- NIH [1 R01 AR070245-01A1]
- Jonsson Comprehensive Cancer Center
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The shift between a proliferating and a nonproliferating state is associated with significant changes in metabolic needs. Proliferating cells tend to have higher metabolic rates, and their metabolic profiles facilitate biosynthesis, as compared to those of nondividing cells of the same sort. Recent studies have elucidated specific molecules that control metabolic changes while cells shift between proliferation and quiescence. Embryonic stem cells, which are rapidly proliferating, tend to have metabolic patterns that are similar to those of nonstem cells in a proliferative state. Moreover, although adult stem cells tend to be quiescent, their metabolic profiles have been reported in multiple organs to more closely resemble those of proliferating than those of nondividing cells in some respects. The findings raise questions about whether there are metabolic profiles that are required for stemness, and whether these profiles relate to the metabolic properties that may be required for quiescence. Here, we review the literature on how metabolism changes upon commitment to proliferation and compare the proliferating and nonproliferating metabolic states of differentiated cells and embryonic and adult stem cells.
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