Journal
FASEB JOURNAL
Volume 33, Issue 11, Pages 11640-11654Publisher
WILEY
DOI: 10.1096/fj.201901175R
Keywords
acetyltransferase; acetyl-CoA; glucose metabolism; target; progression
Categories
Funding
- National Natural Science Foundation of China [31572409]
- Hubei Provincial Natural Science Foundation of China [2018CFA071]
- National Key Research and Development Program [2018YFD0500600]
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Impaired glycolysis has pathologic effects on the occurrence and progression of liver diseases, and it appears that glycolysis is increased to different degrees in different liver diseases. As an important post-translational modification, reversible lysine acetylation regulates almost all cellular processes, including glycolysis. Lysine acetylation can occur enzymatically with acetyltransferases or nonenzymatically with acetyl-coenzyme A. Accompanied by the progression of liver diseases, there seems to be a temporal and spatial variation between enzymatic and nonenzymatic acetylations in the regulation of glycolysis. Here, we summarize the most recent findings on the functions and targets of acetylation in controlling glycolysis in the different stages of liver diseases. In addition, we discuss the differences and causes between enzymatic and nonenzymatic acetylations in regulating glycolysis throughout the progression of liver diseases. Then, we review these new discoveries to provide the potential implications of these findings for therapeutic interventions in liver diseases.
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