Journal
EUROPEAN RADIOLOGY
Volume 30, Issue 3, Pages 1419-1425Publisher
SPRINGER
DOI: 10.1007/s00330-019-06362-x
Keywords
Mammography; Phase contrast; Interferometry
Funding
- FP7 Ideas: European Research Council [2012-StG 310005-PhaseX] Funding Source: Medline
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [CRS112-154472 MedXPhase] Funding Source: Medline
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Objectives Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, as several research works have demonstrated in a pre-clinical setting, since it is able to provide attenuation, differential phase contrast, and scattering images simultaneously. In order to translate this technique to the clinics, it has to be adapted to cover a large field-of-view within a clinically acceptable exposure time and radiation dose. Methods We set up a grating interferometer that fits into a standard mammography system and fulfilled the aforementioned conditions. Here, we present the first mastectomy images acquired with this experimental device. Results and conclusion Our system performs at a mean glandular dose of 1.6 mGy for a 5-cm-thick, 18%-dense breast, and a field-of-view of 26 x 21 cm2. It seems to be well-suited as basis for a clinical-environment device. Further, dark-field signals seem to support an improved lesion visualization. Evidently, the effective impact of such indications must be evaluated and quantified within the context of a proper reader study.
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