Journal
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Volume 240, Issue -, Pages 261-266Publisher
ELSEVIER
DOI: 10.1016/j.ejogrb.2019.07.016
Keywords
Kisspeptin; Pregnancy; Placenta; Pre-eclampsia; Miscarriage
Categories
Funding
- National Key R&D Program of China [2016YFC1000201, 2016YFC1000601]
- National Natural Science Funds for general program [31501201, 81471427, 81771650, 81571400, 81771580]
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Kisspeptins are a family of neuropeptides that are critical for the puberty initiation and female fertility. Plasma or serum kisspeptin is mainly derived from the placenta during pregnancy and plasma kisspeptin levels significantly increase across pregnancy. Plasma kisspeptin levels could be used as a potential biomarker for the detection of miscarriage, pre-eclampsia, gestational trophoblastic neoplasia (GTN), and fetal development. Kisspeptin may also be involved in the process of parturition by stimulating oxytocin secretion during term pregnancy. This review discussed the potential use of kisspeptin as a marker across pregnancy and highlighted the unresolved problems in this area. Tweetable abstract: Plasma kisspeptin levels could be used as a potential biomarker across pregnancy. (C) 2019 Elsevier B.V. All rights reserved.
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