Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 175, Issue -, Pages 215-233Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.04.066
Keywords
alpha-Santonin; Structure-activity relationship; Synthetic strategies; Derivatives; Bioactivities
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Funding
- National Natural Science Foundation of China [81502955]
- Doctoral Scientific Research Foundation of Shanghai Ocean University [A2030214300077]
- Young Teachers Training Program of Shanghai [A12056160002]
- Plan of Innovation Action in Shanghai [14431906000]
- ARDITI-Agencia Regional para o Desenvolvimento da Investigacao Tecnologia e Inovacao through Centro de Quimica da Madeira-CQM+(Madeira 14-20) [M1420-01-0145-FEDER-000005]
- Fundacao para a Ciencia e a Tecnologia (CQM, Portuguese Government funds) [PEst-OE/QUINI0674/2019]
- project PROEQUI PRAM-Reforco do Investimento em Equipamentos e Infraestruturas Cientificas na RAM [M1420-01-0145- FEDER-000008]
- [ARDITI-2017-ISG-003]
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alpha-Santonin, a sesquiterpene lactone isolated from Artemisia Santonica, possesses diverse bioactivities including antioxidant, anti-inflammation, immunosuppressive, anti-roundworm, anti-malaria, etc. However, its bioactivities are not satisfactory and need to be further optimized. Thus, many alpha-santonin derivatives were synthesized on the basis of rings A, B and C for the discovery of new analogues with prominent bioactivities. Herein, we reviewed and discussed the related synthetic methodologies, diverse bioactivities and structure-activity relationships (SAR) of alpha-santonin derivatives. (C) 2019 Elsevier Masson SAS. All rights reserved.
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