Journal
EXTRACELLULAR MATRIX
Volume 63, Issue 3, Pages 417-432Publisher
PORTLAND PRESS LTD
DOI: 10.1042/EBC20190001
Keywords
-
Categories
Funding
- Department of Physiology and Biophysics at the University of Illinois at Chicago [C-088]
- Catalyst Award from the Chicago Biomedical Consortium
- Searle Funds at the Chicago Community Trust
- Honors College at the University of Illinois at Chicago
Ask authors/readers for more resources
The extracellular matrix (ECM) is a complex assembly of hundreds of proteins that constitutes the scaffold of multicellular organisms. In addition to providing architectural and mechanical support to the surrounding cells, it conveys biochemical signals that regulate cellular processes including proliferation and survival, fate determination, and cell migration. Defects in ECM protein assembly, decreased ECM protein production or, on the contrary, excessive ECM accumulation, have been linked to many pathologies including cardiovascular and skeletal diseases, cancers, and fibrosis. The ECM thus represents a potential reservoir of prognostic biomarkers and therapeutic targets. However, our understanding of the global protein composition of the ECM and how it changes during pathological processes has remained limited until recently. In this mini-review, we provide an overview of the latest methodological advances in sample preparation and mass spectrometry-based proteomics that have permitted the profiling of the ECM of now dozens of normal and diseased tissues, including tumors and fibrotic lesions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available