Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 18, Pages 3810-3815Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.07.080
Keywords
RON; c-Met; RTK inhibitors; Head group; Molecular docking; RON homology model; Oncology
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New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b] pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained. (C) 2015 Elsevier Ltd. All rights reserved.
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