4.3 Article

Renovascular Hypertension

Journal

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ecl.2019.08.007

Keywords

Renovascular disease; Renal artery stenosis; Ischemic nephropathy; Hypertension; Renin and angiotensin

Funding

  1. NIDDK [RO1 DK100081, K08 DK118120]
  2. NIH/National Center for Research Resources

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Renovascular disease (RVD) is a major cause of secondary hypertension. Atherosclerotic renal artery stenosis is the most common type of RVD followed by fibromuscular dysplasia. It has long been recognized as the prototype of angiotensin-dependent hypertension. However, the mechanisms underlying the physiopathology of hypertensive occlusive vascular renal disease are complex and distinction between the different causes of RVD should be made. Recognition of these distinct types of RVD with different degrees of renal occlusive disease is important for management. The greatest challenge is to individualize and implement the best approach for each patient in the setting of widely different comorbidities.

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