Journal
EMBO JOURNAL
Volume 38, Issue 19, Pages -Publisher
WILEY
DOI: 10.15252/embj.2019101688
Keywords
hair cycle; hair follicle; lymphatic vessels; skin; stem cells
Categories
Funding
- Spanish Ministry of Economy and Competitiveness/European Regional Development Fund (ERDF), European Union [BFU2015-71376-R]
- Worldwide Cancer Research UK Foundation [15-1219]
- Novo Nordisk Foundation [NNF17OC0028028]
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Lymphatic vessels are essential for skin fluid homeostasis and immune cell trafficking. Whether the lymphatic vasculature is associated with hair follicle regeneration is, however, unknown. Here, using steady and live imaging approaches in mouse skin, we show that lymphatic vessels distribute to the anterior permanent region of individual hair follicles, starting from development through all cycle stages and interconnecting neighboring follicles at the bulge level, in a stem cell-dependent manner. Lymphatic vessels further connect hair follicles in triads and dynamically flow across the skin. At the onset of the physiological stem cell activation, or upon pharmacological or genetic induction of hair follicle growth, lymphatic vessels transiently expand their caliber suggesting an increased tissue drainage capacity. Interestingly, the physiological caliber increase is associated with a distinct gene expression correlated with lymphatic vessel reorganization. Using mouse genetics, we show that lymphatic vessel depletion blocks hair follicle growth. Our findings point toward the lymphatic vasculature being important for hair follicle development, cycling, and organization, and define lymphatic vessels as stem cell niche components, coordinating connections at tissue-level, thus provide insight into their functional contribution to skin regeneration.
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