Journal
EMBO JOURNAL
Volume 38, Issue 19, Pages -Publisher
WILEY
DOI: 10.15252/embj.2019103148
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Categories
Funding
- National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases [DK078803, DK068471, DK094989, DK105129, DK110406, DK083355]
- Alvin J. Siteman Cancer Center/Barnes Jewish Hospital Foundation Cancer Frontier Fund
- NIH National Cancer Institute [P30CA091842]
- Novartis Institutes for BioMedical Research
- Keystone Symposia Director's Fund
- Keystone Symposia Future of Science Fund
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It is now recognized that cell identity is more fluid, and tissues more plastic, than previously thought. The plasticity of cells is relevant to diverse fields, most notably developmental and stem cell biology, regenerative medicine, and cancer biology. To date, a comprehensive and uniform nomenclature to define distinct cell states and their injury-induced interconversions has been elusive. The first Keystone Symposium devoted exclusively to cellular plasticity in regeneration and tumorigenesis was held on January 2019 in Keystone, Colorado, and featured a workshop on terminology in the cell plasticity field. Definitions for terms such as plasticity, de- and transdifferentiation, reversion, and paligenosis were discussed. Here, we summarize the content and tenor of the symposium and nomenclature-focused workshop with regard to terms in the field. We outline the challenges with current definitions and recommend best practices and approaches to developing an accurate and acceptable nomenclature in the future.
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