Dissipation and safety evaluation of afidopyropen and its metabolite residues in supervised cotton field

The novel insecticidal mechanism of afidopyropen can be substituted for traditional pesticides to control sap sucking pests in cotton field. The data of residue amounts of afidopyropen and its metabolite M4401007 in cotton matrix and the environment soil are important to evaluate the safe use of the target compound and establish maximum residue limit (MRL). In this work, the dissipation and residue of afidopyropen and its metabolite M4401007 in cotton and field soils were investigated. The analytical methods of the target compound in cotton plants, cottonseed, crude cottonseed oil, cottonseed oil and soil were developed and quantified by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS), which satisfied the rules of pesticide residue determination. The dissipation half-lives of afidopyropen in cotton plants and soil ranged from 1 to 3 days and 4-13 days, respectively. After 14 days from the last application, the residues of afidopyropen were below 0.01 mg/kg in cottonseed and were < 0.005-0.0099 mg/kg in soil, and the residues of M4401007 were below 0.02 mg/kg in cottonseed and below 0.01 mg/kg in soil. The total national estimated daily intake (NEDI) of afidopyropen was 1.41 mg and the risk quotient (RQ) was 28.0%. The results showed that the risk of application of afidopyropen with the recommended dosage was acceptable.