Journal
DRUG DEVELOPMENT RESEARCH
Volume 80, Issue 8, Pages 1120-1127Publisher
WILEY
DOI: 10.1002/ddr.21596
Keywords
HIF-1 alpha; preeclampsia; TFPI-2; VEGF; vitexin
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Funding
- Hebei Science and Technology Support Project [17277739D]
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Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality with few safe, effective, and minimally invasive therapeutics. Inflammation, oxidative stress, and angiogenic imbalance have been reported to contribute to PE pathogenesis. Vitexin (VI) possesses various pharmacological activities including the potent regulation of the above biological processes in different conditions. This study aims to investigate whether VI has therapeutic potential to PE and the underlying mechanisms. Sprague-Dawley pregnant rats pretreated with or without VI were fed with l-NAME-containing water to induce experimental PE. Results showed that VI decreased high systolic blood pressure and urinary protein in PE rats time- and dose-dependently. Meanwhile, VI of higher dosage (45, 60 mg/kg) corrected abnormal pregnancy outcomes, including low pup weight and low pups/placenta ratio. In addition, VI of high dosage (60 mg/kg) decreased sFlt-1, increased PlGF and alleviated oxidative stress both in blood and placental samples compared with nontreated PE group. Furthermore, VI alleviated placental TFPI-2, HIF 1 alpha, and VEGF in PE rats. In short, the present study suggests that the inhibition of placental TFPI-2 and HIF-1 alpha/VEGF might be one of the potential mechanisms underlying the protective effects of VI to experimental PE induced by l-NAME.
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