Journal
DRUG DEVELOPMENT RESEARCH
Volume 81, Issue 2, Pages 165-183Publisher
WILEY
DOI: 10.1002/ddr.21587
Keywords
Alzheimer's; alkaloid; flavonoid; multitarget ligand
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Funding
- Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India [NIPER-R/Communication/066]
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Alzheimer's disease (AD), a complex neurodegenerative disorder causing multiple cellular changes including impaired cholinergic system, beta-amyloid (beta A) aggregation, tau hyperphosphorylation, metal dyshomeostasis, neuroinflammation, and many other pathways are involved in the pathogenesis of the disease. However, the exact cause of the disease is not known. Natural products such as flavonoids, alkaloids, resveratrol, and curcumin have multifunctional properties, and have drawn the attention of the researchers because these molecules are capable of interacting concurrently with the multiple targets of AD. Therefore, natural products and their derivatives with proven efficacy could be used in the management of the neurodegenerative disorders. This review focuses on the natural product based multitarget directed ligands like tacrine-coumarin, tacrine-huperzine A, harmine-isoxazoline, berberine-thiophenyl, galantamine-indole, pyridoxine-resveratrol, donepezil-curcumin and their mode of action.
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