Protective effects of diarylpropionitrile against hydrogen peroxide-induced damage in human neuroblastoma SH-SY5Y cells

Oxidative stress is implicated in pathogenesis of neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. The study demonstrates diarylpropionitrile (DPN), an antioxidant selective agonist of estrogen receptor beta, protected human neuroblastoma SH-SY5Y cells against H2O2-induced toxicity by attenuating production of reactive oxygen species, apoptosis, autophagy, NF-kappa B activation, MAPK p38, JNK and ERK 1/2 signaling pathways, and beta-site amyloid precursor protein cleaving enzyme level, but, interestingly, stimulating Akt pathway. These findings indicate the important potential of DPN to ameliorate oxidative stress-associated damage in neurodegenerative disorders.

Automated summary

The study shows that DPN, an antioxidant selective agonist of estrogen receptor beta, can protect neuroblastoma cells from oxidative stress by attenuating various pathways involved in cell damage, indicating its potential in ameliorating neurodegenerative disorders.