Journal
DNA AND CELL BIOLOGY
Volume 38, Issue 8, Pages 874-879Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2018.4308
Keywords
resveratrol; amyloid-beta protein; activation; neuroinflammation; TXNIP; TRX; NLRP3
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Microglia-mediated neuroinflammation plays an important role in Alzheimer's disease development. Resveratrol, a natural polyphenol from the Japanese knotweed (Polygonum cuspidatumand), is known to protect against neuroinflammation, but the mechanism remains unclear. To begin to explore potential mechanisms, we created a model of inflammatory injury in BV-2 murine microglial cells based on the induction of amyloid-beta. We found that resveratrol (10 and 50 nM) significantly inhibited A beta-induced proliferation and activation of BV-2 cells, as well as their release of the proinflammatory cytokines, IL-6 and TNF-alpha. Resveratrol also suppressed the overexpression of cleaved caspase-1 and IL-1 beta, and decreased A beta-stimulated degradation of IkB alpha and phosphorylation of NF-kappa B phosphorylation. Western blot analysis showed that A beta upregulated the TXNIP/TRX/NLRP3 pathway, while resveratrol treatment inhibited it. We conclude that resveratrol protects microglia from A beta-stimulated inflammation by suppressing the inflammatory response, at least in part by inhibiting the TXNIP/TRX/NLRP3 signaling pathway.
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