Journal
DIABETES OBESITY & METABOLISM
Volume 22, Issue 3, Pages 458-462Publisher
WILEY
DOI: 10.1111/dom.13879
Keywords
continuous glucose monitoring; DPP-4 inhibitor; randomized trial; SGLT2 inhibitor; type 2 diabetes
Categories
Funding
- Mitsubishi Tanabe Pharma Corporation
Ask authors/readers for more resources
This multicentre, prospective, randomized, open-label, blinded-endpoint, parallel-group, short-term (4-5 weeks) controlled trial was conducted to investigate the superiority of the effect of reducing mean amplitude of glycaemic excursions (MAGE) during meal tolerance tests (MTTs) for the combination of dipeptidyl peptidase-4 (DPP-4) inhibitor and sodium-glucose co-transporter-2 (SGLT2) inhibitor compared with SGLT2 inhibitor monotherapy. Ninety-nine patients with type 2 diabetes who were taking teneligliptin (20 mg/d) were randomized to one of the following two groups: those who switched to 100 mg/d of canagliflozin (SWITCH group) or those who added 100 mg/d of canagliflozin (COMB group). MAGE in the COMB group was significantly decreased compared with that in the SWITCH group (COMB 117.5 +/- 39.8 to 92.2 +/- 28.0 mg/dL vs SWITCH 110.7 +/- 29.8 to 104.2 +/- 27.6 mg/dL; P<0.01). Mean blood glucose decreased significantly during MTTs in both groups, although the extent of the reduction was significantly greater in the COMB group (COMB 142.3 +/- 28.7 to 119.5 +/- 25.1 mg/dL vs SWITCH 146.4 +/- 25.5 to 135.5 +/- 22.4 mg/dL; P < 0.01). SGLT2 inhibitor combined with DPP-4 inhibitor therapy strongly reduced glycaemic fluctuation compared with SGLT2 inhibitor monotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available