Journal
DEVELOPMENT
Volume 146, Issue 17, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.148296
Keywords
Bone; Development; Hematopoiesis; RUNX; T cell; Embryonic
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Funding
- Medical Research Council [MR/P000673/1]
- Biotechnology and Biological Sciences Research Council [BB/I001794/1, BB/R007209/1]
- European Union's Horizon 2020 [GA6586250]
- Cancer Research UK [C5759/A20971]
- BBSRC [BB/R007209/1, BB/I001794/1] Funding Source: UKRI
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RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes. stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.
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