Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 47, Issue -, Pages 53-58Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2019.02.005
Keywords
-
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tcenologico do Brasil (CNPQ)
- Coordenacao de Aperfeicoamento de Pessoal dc Nivel Superior (CAPES)
- Fundacao de Amparo a Pcsquisa do Estado do Rio dc Janeiro (FAPERJ)
Ask authors/readers for more resources
Adenosine triphosphate (ATP) is released from host cells during parasite infections and acts as a danger signal in the extracellular space by activating plasma membrane purinergic type 2 receptors-P2 receptors. The activation of these receptors has been described as a crucial step in immune cell activation, inflammation and parasite control. The P2X7 receptor is most involved in the activation of host microbicidal mechanisms, including production of reactive oxygen and nitrogen species, phagolysosomal fusion, acidification of parasitophorous vacuoles and release of cytokines and chemokines. The P2X7 receptor also modulates adaptive immune responses in various infectious diseases. Here, we discuss key points from the recent literature regarding P2X7 receptor activation during intracellular parasite infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available