Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 57, Issue -, Pages 149-155Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2019.02.001
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Funding
- University of California, San Diego institutional funds
- Parkinson's Foundation [PF-JFA-1888]
- National Institutes of Health [R35GM128823]
- NIH Training Grant [T32NS061847]
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Neurons are highly polarized cells with extraordinary energy demands, which are mainly fulfilled by mitochondria. In response to altered neuronal energy state, mitochondria adapt to enable energy homeostasis and nervous system function. This adaptation, also called mitochondria) plasticity, can be observed as alterations in the form, function and position. The primary site of energy consumption in neurons is localized at the synapse, where mitochondria are critical for both pre- and postsynaptic functions. In this review, we will discuss molecular mechanisms regulating mitochondrial plasticity at the synapse and how they contribute to information processing within neurons.
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