Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 57, Issue -, Pages 87-93Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2019.01.015
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Funding
- U.S. Department of Defense [PR150380]
- National Institute of Health [RO1NS089583]
- Archer Fund
- Stanford Parkinson's Disease Seed Grant
- Belgian American Education Foundation
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Neurons need to allocate and sustain mitochondria to provide adequate energy and sufficient Ca2+-buffering capacity in each sub specialization of their extensive arborizations. Damaged mitochondria, which are highly deleterious to the neuron, must be rapidly repaired or eliminated, even when they are left at terminals extremely far away from the soma. The unique shape of neurons complicates the tasks of both transporting and clearing mitochondria. Errors in the underlying molecular regulations cause detrimental neurodegeneration. Here, we review the molecular machinery and regulatory mechanisms employed to transport, distribute, and clear mitochondria in neurons, and how these fundamental regulations are compromised in neurological disorders.
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